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PDQ_MED Navigation
 
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Gene libraries provide a wealth of information on the genes expressed by a particular tissue. Frequently, many of the genes are known in the literature, but until now, no practical method for exploring the possible interconnections between the genes existed. PDQ_MED provides an effective tool for identifying and exploring the relationships between a set of genes. PDQ_MED exhaustively searches and analyses the more than 10 million abstracts in MEDLINE for relationships between the set of genes under investigation. The analysis includes co-occurance, proximity checking and weighting based on total term frequencies.
The researcher inputs a list of gene, tissue or disease terms, including alternate names and pseudonyms, and may restrict the search by language or date. Other MEDLINE search options are also supported, including title and author searches. In addition, the reseracher may define a list of pharma terms.
PDQ_MED returns clustered groupings of the scientific literature, suggesting possible interactions and inter-relationships between the genes of the query list. Results are presented in graphical form, as highlighted sentences and as links back to the original literature.
PDQ_MED provides an analysis capability that is available nowhere else. It quickly identifies literature that suggests how a set of genes may be functionally related, with particular emphasis on pharma relevant concepts and relationships. PDQ_MED is indispensable for the analysis of shotgun, differential display and subtracted libraries as well as gene chip studies.